Miguel Díaz-Canel spoke to crowds in Havana the US is trying to destroy Cuba’s political system.
He declared America aims for full control over the island.
Díaz-Canel called US policies a case of political genocide during July 26 events.
He warned this is a menace to the country's right to govern.
Raúl Castro stayed away from the main rally.
Tensions remain high due to sanctions and US political pressure.